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KMID : 0380620220540030327
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 3 p.327 ~ p.333
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Development and characterization of hyaluronic acid-based orally disintegrating film containing vitamin D
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Kang Seo-Yeon
An Da-Yeon
Han Jung-Ah
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Abstract
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An orally disintegrating film (ODF) based on hyaluronic acid (HA) containing vitamin D was developed. The vitamin D content in the ODF was set based on the adequate intake (AI) of vitamin D from 0 to 10 AI (0, 1, 4, 7, and 10AI). The control (0AI) had the highest thickness and showed the longest disintegration time among the samples. The moisture content of the ODFs was significantly lower in those with vitamin D compared to the control. As the amount of vitamin D increased, the water vapor permeability (WVP) of the ODFs decreased, and the opacity significantly increased. The tensile strength was higher in the films containing vitamin D compared to the control films. However, the elongation at the break showed no significant difference among the films. The vitamin D content in the film was reduced by 25.7-44.2% during processing compared to the amount that was originally added. Based on the above results, a new and convenient vitamin D delivery system, an ODF, could be successfully produced.
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KEYWORD
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ODF, hyaluronic acid, vitamin D, disintegrating time
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